Capturing single L-type Ca2+ channel function with optics
نویسندگان
چکیده
منابع مشابه
Single-Channel Demonstration of L-Type Ca2+ Window Current
Canine cardiac Purkinje cells contain both Land T-type calcium currents, yet the single Ca2' channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activation curves for L-type Ca2' currents, suggesting the presence of L-type Ca2' "window" current. We used the on-cell, patch-clamp technique to study C...
متن کاملL- and T-type Ca2+ channels in canine cardiac Purkinje cells. Single-channel demonstration of L-type Ca2+ window current.
Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-type Ca2+ "window" current. We used the on-cell, patch-clamp technique to stud...
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L-TYPE CA2 CHANNELS PLAY a pivotal role in regulating cellular excitability and contractility in cardiac tissue. Ca influx through these channels [L-type Ca current (ICa,L)] contributes to the plateau phase of the ventricular action potential and initiates excitation-contraction coupling by activating Ca release channels or ryanodine receptors in the sarcoplasmic reticulum (1). The resulting Ca...
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During the cardiac action potential, Ca(2+) entry through dyhidropyridine receptor L-type Ca(2+) channels (DHPRs) activates ryanodine receptors (RyRs) Ca(2+)-release channels, resulting in massive Ca(2+) mobilization from the sarcoplasmic reticulum (SR). This global Ca(2+) release arises from spatiotemporal summation of many localized elementary Ca(2+)-release events, Ca(2+) sparks. We tested w...
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Cellular Ca(2+) signaling underlies diverse vital biological processes, including muscle contractility, memory encoding, fertilization, cell survival, and cell death. Despite extensive studies, the fundamental control mechanisms that regulate intracellular Ca(2+) movement remain enigmatic. We have found recently that activation of the (Na(+)+K(+))-ATPase markedly potentiates intracellular Ca(2+...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2013
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2012.10.027